PATHOPHYSIOLOGY:
"Autism" has been associated with a variety of
disorders affecting the central nervous system
- i.e. encephalitis, encephalopathy
Three children - autistic features resolved after
clinical recovery (1981, DeLong, Bean, and Brown)
- One patient - high serum herpes simplex titers
- CT scan - lesion - temporal lobes
4-year old girl - a “typical” autistic syndrome after an
attack of herpes simplex encephalitis (1986, Gillberg)
- CT - Temporal lobes
- Some involvement (lower parts) parietal lobes